Regioselective Synthesis of Tetrahydrothiochromen-5-ones via a One-Pot Three-Component Solvent-Free Domino Protocol

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• 作者：Sushobhan Chowdhury ; Ganesh Chandra Nandi ; Subhasis Samai ; Maya Shankar Singh
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：July 15, 2011
• 年：2011
• 卷：13
• 期：14
• 页码：3762-3765
• 全文大小：745K
• 年卷期：v.13,no.14(July 15, 2011)
• ISSN：1523-7052

文摘

A highly efficient one-pot three-component regioselective synthesis of 4-aryl-3-aroyl-2-methylsulfanyl-4,6,7,8-tetrahydrothiochromen-5-ones has been developed by annulation of 尾-oxodithioesters with aldehydes and cyclic 1,3-diketones under solvent-free conditions promoted by P₂O₅. No cocatalyst or activator is needed in this protocol. The merit of this process is highlighted by its high efficiency of producing three new bonds and a stereocenter in one operation.