Palladium Catalyzed Oxidative Coupling of 伪-Enolic Dithioesters: A New Entry to 3,4,5-Trisubstituted 1,2-Dithioles via a Double Activation Strategy

详细信息    查看全文

• 作者：Sushobhan Chowdhury ; Tanmoy Chanda ; Suvajit Koley ; B. Janaki Ramulu ; Raymond C. F. Jones ; Maya Shankar Singh
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：15
• 期：20
• 页码：5386-5389
• 全文大小：301K
• 年卷期：v.15,no.20(October 18, 2013)
• ISSN：1523-7052

文摘

An operationally simple, facile, and convenient one-pot straightforward method for the construction of 3,4,5-trisubstituted 1,2-dithioles has been explored and developed via palladium catalyzed self-coupling of 伪-enolic dithioesters for the first time. Pd(0) efficiently catalyzes the activation and cleavage of S鈥揌 and C鈥揝 bonds to achieve cascade coupling, which results in the concomitant formation of new S鈥揝 and C鈥揅 bonds. Optimization data, substrate scope, and mechanistic insights are discussed.