Vibsatins A and B, Two New Tetranorvibsane-Type Diterpenoids from Viburnum tinus cv. variegatus
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- 作者：Xiu Gao ; Li-Dong Shao ; Liao-Bin Dong ; Xiao Cheng ; Xing-De Wu ; Fei Liu ; Wei-Wei Jiang ; Li-Yan Peng ; Juan He ; Qin-Shi Zhao
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：February 7, 2014
- 年：2014
- 卷：16
- 期：3
- 页码：980-983
- 全文大小：268K
- ISSN：1523-7052
文摘
Vibsatins A (1) and B (2), a pair of 14,15,16,17-tetranorvibsane-type diterpenoids that feature a bicyclo[4.2.1]nonane moiety formed by a new C-13/C-2 bond, were isolated from the twigs and leaves of Viburnum tinus cv. variegatus. The structures and absolute configurations were elucidated by a combination of NMR spectra, optical rotation, and X-ray diffraction experiments. A possible biogenetic pathway is also proposed. Moreover, vibsatin A (1) enhanced the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 渭M.