In Situ Proteome Profiling of C75, a Covalent Bioactive Compound with Potential Anticancer Activities

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• 作者：Xiamin Cheng ; Lin Li ; Mahesh Uttamchandani ; Shao Q. Yao
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1414-1417
• 全文大小：320K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

A library of cell-permeable, minimally tagged C75 analogues was synthesized and used to uncover biological targets in human liver cancer cells. Known targets of C75, namely FASN and CPT1A, together with other unknown targets, including PDIA3, TFRC, and GAPDH, were thus identified.