SP1 Protein-Based Nanostructures and Arrays

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• 作者：Izhar Medalsy ; Or Dgany ; Mukhles Sowwan ; Hezy Cohen ; Alevtyna Yukashevska ; Sharon G. Wolf ; Amnon Wolf ; Abraham Koster ; Orna Almog ; Ira Marton ; Yehonathan Pouny ; Arie Altman ; Oded Shoseyov ; Danny Porath
• 刊名：Nano Letters
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：8
• 期：2
• 页码：473 - 477
• 全文大小：743K
• 年卷期：v.8,no.2(February 2008)
• ISSN：1530-6992

文摘

Controlled formation of complex nanostructures is one of the main goals of nanoscience and nanotechnology. Stable Protein 1 (SP1) is aboiling-stable ring protein complex, 11 nm in diameter, which self-assembles from 12 identical monomers. SP1 can be utilized to form largeordered arrays; it can be easily modified by genetic engineering to produce various mutants; it is also capable of binding gold nanoparticles(GNPs) and thus forming protein-GNP chains made of alternating SP1s and GNPs. We report the formation and the protocols leading to theformation of those nanostructures and their characterization by transmission electron microscopy, atomic force microscopy, and electrostaticforce microscopy. Further control over the GNP interdistances within the protein-GNP chains may lead to the formation of nanowires andstructures that may be useful for nanoelectronics.