Visible Light-Mediated C鈥揌 Difluoromethylation of Electron-Rich Heteroarenes

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• 作者：Yi-Ming Su ; Yu Hou ; Feng Yin ; Yue-Ming Xu ; Yan Li ; Xiaoqi Zheng ; Xi-Sheng Wang
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 6, 2014
• 年：2014
• 卷：16
• 期：11
• 页码：2958-2961
• 全文大小：385K
• 年卷期：v.16,no.11(June 6, 2014)
• ISSN：1523-7052

文摘

A novel method for visible-light photoredox-catalyzed difluoromethylation of electron-rich N-, O-, and S-containingheteroarenes under mild reaction conditions is developed. Mechanistic investigation indicates that the net C鈥揌 difluoromethylation proceeds through an electrophilic radical-type pathway.