Dihydroagarofuranoid Sesquiterpenes, a Lignan Derivative, a Benzenoid, and Antitubercular Constituents from the Stem of Microtropis japonica
文摘
Four new compounds, including two new dihydroagarofuranoid sesquiterpenes, 8-benzoyloxymutangin (1) and 15-acetoxyorbiculin G (2), a new lignan derivative, 9,9′-O-di-(Z)-feruloyl-(−)-secoisolariciresinol (3), and a new benzenoid, 5′-methoxyevofolin B (4), have been isolated from the stem of Microtropis japonica, together with 20 known compounds (5−24). 3-Ethoxy-4-hydroxybenzaldehyde (5) was identified from a natural source for the first time. The structures of these new compounds were determined through analyses of physical data. 15-Acetoxyorbiculin G (2), celahin C (6), and salasol A (7) exhibit antituberculosis activities (MICs ≤ 39.6 µM) against Mycobacterium tuberculosis H37Rv in vitro.