A Highly Convergent and Efficient Synthesis of a Macrocyclic Hepatitis C Virus Protease Inhibitor BI 201302
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- 作者：Xudong Wei ; Chutian Shu ; Nizar Haddad ; Xingzhong Zeng ; Nitinchandra D. Patel ; Zhulin Tan ; Jianxiu Liu ; Heewon Lee ; Sherry Shen ; Scot Campbell ; Richard J. Varsolona ; Carl A. Busacca ; Azad Hossain ; Nathan K. Yee ; Chris H. Senanayake
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：March 1, 2013
- 年：2013
- 卷：15
- 期：5
- 页码：1016-1019
- 全文大小：262K
- 年卷期：v.15,no.5(March 1, 2013)
- ISSN：1523-7052
文摘
A highly convergent large scale synthesis of a 15-membered macrocyclic hepatitis C virus (HCV) protease inhibitor BI 201302 was achieved, in which the key features are the practical macrocyclization by Ru-catalyzed ring-closing metathesis (0.1 mol % Grela catalyst, 0.1鈥?.2 M concentration) and the efficient sulfone-mediated SNAr reaction.