Anti-inflammatory Flavonoids from the Rhizomes of Helminthostachys zeylanica

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• 作者：Yaun-Chao Huang ; Tsong-Long Hwang ; Chih-Shiang Chang ; Yu-Liang Yang ; Chia-Ning Shen ; Wen-Ying Liao ; Sheng-Chih Chen ; Chih-Chuang Liaw
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：July 24, 2009
• 年：2009
• 卷：72
• 期：7
• 页码：1273-1278
• 全文大小：135K
• 年卷期：v.72,no.7(July 24, 2009)
• ISSN：1520-6025

文摘

Eight new prenylated flavonoids, ugonins M−T (1-8), together with five known compounds, ugonins J−L (9−11), 5,4′-dihydroxy-4′′,4′′-dimethyl-5′′-methyl-5′′H-dihydrofurano[2′′,3′′:6,7]flavanone, and quercetin, were isolated and purified from the rhizomes of Helminthostachys zeylanica. The structures of the new isolates were elucidated by spectroscopic and chemical methods. Compounds 1, 3, 5, 7, 8, and 11 showed inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (FMLP/CB).