δ-Tocotrienol Suppresses VEGF Induced Angiogenesis whereas α-Tocopherol Does Not

详细信息    查看全文

• 作者：Akira Shibata ; Kiyotaka Nakagawa ; Phumon Sookwong ; Tsuyoshi Tsuduki ; Shinichi Oikawa ; Teruo Miyazawa
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：September 23, 2009
• 年：2009
• 卷：57
• 期：18
• 页码：8696-8704
• 全文大小：960K
• 年卷期：v.57,no.18(September 23, 2009)
• ISSN：1520-5118

文摘

Recently, tocotrienol (T3), a less well-known form of vitamin E, has gained considerable attention as a potent antiangiogenic agent. However, the majority of vitamin E research has focused on tocopherol (Toc), with some studies indicating α-Toc may prevent tumor angiogenesis. In this study, we aimed to clarify the differences in antiangiogenic potential between δ-T3 and α-Toc. We showed δ-T3 (2.5−5 μM) completely abolished proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs), whereas a similar dose of α-Toc had no such effects. δ-T3 suppressed VEGF receptor 2 (VEGFR-2) signaling, and activated caspases in HUVECs. In addition, via an in vivo mouse Matrigel plug angiogenesis assay, we found that δ-T3 (30 μg), but not α-Toc, inhibited tumor cell-induced vessel formation. In summary, our results demonstrate δ-T3 has superior antiangiogenic activities to α-Toc, and provide insights into the different mechanisms responsible for this effect of T3 and Toc.