Nonionic Block Copolymers Assemble on the Surface of Protein Bionanoparticle

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• 作者：Zhi Liu ; Jingxia Gu ; Man Wu ; Shidong Jiang ; Dayong Wu ; Qian Wang ; Zhongwei Niu ; Yong Huang
• 刊名：Langmuir
• 出版年：2012
• 出版时间：August 21, 2012
• 年：2012
• 卷：28
• 期：33
• 页码：11957-11961
• 全文大小：277K
• 年卷期：v.28,no.33(August 21, 2012)
• ISSN：1520-5827

文摘

Efficient delivery of therapeutic proteins to a target site remains a challenge due to rapid clearance from the body. Here, we selected tobacco mosaic virus (TMV) as a model protein system to investigate the interactions between the protein and a nonionic block copolymer as a possible protecting agent for the protein. By varying the temperature, we were able to obtain core鈥搒hell structures based on hydrophobic interactions among PO blocks and noncovalent interactions between TMV and EO blocks. The protein鈥損olymer interactions were characterized by dynamic light scattering and isothermal titration calorimetry. This study establishes principles for the possible design of clinically useful protein delivery systems.