Thermoresponsive Synthetic Polymer鈥揗icrotubule Hybrids

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• 作者：Kiyotaka Shigehara ; Hiroki Kudoh ; Takamasa Sakai ; Yoshihito Osada ; Yoshihiko Murakami ; Kazuhiro Shikinaka
• 刊名：Langmuir
• 出版年：2013
• 出版时间：September 17, 2013
• 年：2013
• 卷：29
• 期：37
• 页码：11786-11792
• 全文大小：425K
• 年卷期：v.29,no.37(September 17, 2013)
• ISSN：1520-5827

文摘

Thermoresponsive hybrids consisting of synthetic polymers and microtubules (MTs), i.e., assemblies of tubulins, were prepared by bonding MTs covalently to a few reactive units in a macromolecular strand. The hybrids exhibited the gel/sol transition because of the 鈥渁ssembling of tubulins to MTs/disintegrating of MTs to tubulins鈥?by the temperature change between 37 and 4 掳C, respectively. The viscoelastic behaviors of the hybrid gels depended upon the quantity of polymer feed and the amount of resulting covalent bonds between the polymers and tubulin units. Furthermore, in a confined space of a thin and long rectangular cell with the temperature gradient from 4 掳C (cold terminal) to 37 掳C (warm terminal), the sol state hybrid turned to the gel state that propagated from the warm terminal toward the cold terminal to form uniaxially oriented MT arrays. Upon changing the temperature of the whole system between 37 and 4 掳C, the uniaxial arrays appeared/disappeared reversibly.