One-Pot Synthesis of Linear-Hyperbranched Amphiphilic Block Copolymers Based on Polyglycerol Derivatives and Their Micelles

详细信息    查看全文

• 作者：Yurie Oikawa ; Sueun Lee ; Do Hyung Kim ; Dae Hwan Kang ; Byeong-Su Kim ; Kyohei Saito ; Shigeko Sasaki ; Yoshiyuki Oishi ; Yuji Shibasaki
• 刊名：Biomacromolecules
• 出版年：2013
• 出版时间：July 8, 2013
• 年：2013
• 卷：14
• 期：7
• 页码：2171-2178
• 全文大小：520K
• 年卷期：v.14,no.7(July 8, 2013)
• ISSN：1526-4602

文摘

This paper describes the one-pot synthesis of a polyglycidol (PG)-based polymer, poly(ethoxyethyl glycidyl ether) (PEEGE)-b-[hyperbranched polyglycerol (hbPG)-co-PEEGE]_x/y, its micelle formulation, and the ability to encapsulate a model therapeutic molecule. Amphiphilic block copolymers were prepared by the sequential addition of ethoxyethyl glycidyl ether (EEGE) to glycidol. The composition of the block copolymers varied from 62:38 to 92:8. Block copolymers with composition x:y 鈮?66:34 were soluble only in organic solvents. Micelles were formulated by injection of deionized water into a tetrahydrofuran block copolymer solution with or without pyrene as a model hydrophobic molecule. The critical micelle concentration was 18.2鈥?0.9 mg/L, and the micelle size was 100鈥?50 nm. The pyrene-containing micelle rapidly collapsed on acidic exposure, allowing conversion of hydrophobic PEEGE to hydrophilic PG, thus, facilitating the release of the encapsulated pyrene. Cytotoxicity data showed high biocompatibility of PG-based block copolymers, suggesting their potential as a drug delivery carrier.