The First Total Synthesis of (-) and (+)-2-Hydroxy-24-oxooctacosanolide Using an Effective Lactonization

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• 作者：Isamu Shiina ; Takaaki Kikuchi ; Akane Sasaki
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：October 12, 2006
• 年：2006
• 卷：8
• 期：21
• 页码：4955 - 4958
• 全文大小：94K
• 年卷期：v.8,no.21(October 12, 2006)
• ISSN：1523-7052

文摘

An effective method for the total synthesis of 2-hydroxy-24-oxooctacosanolide, a defensive salivary secretion of the African termitePseudacanthotermes spiniger, has been developed. The key lactonization to form a 29-membered ring lactone core is performed using 2-methyl-6-nitrobenzoic anhydride with a catalytic amount of 4-(dimethylamino)pyridine N-oxide.