Dietary Docosahexaenoic Acid Can Alter the Surface Expression of CD4 and CD8 on T Cells in Peripheral Blood

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• 作者：Taku Sasaki ; Yusuke Kanke ; Masahito Nagahashi ; Maki Toyokawa ; Michiyo Matsuda ; Jun Shimizu ; Yoshihisa Misawa ; and Toshichika Takita
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2000
• 出版时间：April 2000
• 年：2000
• 卷：48
• 期：4
• 页码：1047 - 1049
• 全文大小：33K
• 年卷期：v.48,no.4(April 2000)
• ISSN：1520-5118

文摘

The effect of dietary docosahexaenoic acid (DHA) on T cell states in peripheral blood was investigated.Weanling male C57Bl/6N mice were kept on one of three 10% fat diets containing various amountsof DHA and linoleic acid for 4 weeks. Changing the concentration of dietary DHA did not alter theproportion of T cells expressing CD4 or CD8. However, increasing the concentration of dietary DHAlowered the expression of CD4 and CD8 on the cell surface. The decreased expression of these surfacemolecules involved in T cell proliferation has serious implications in the role of DHA as animmunosuppressant.Keywords: Docosahexaenoic acid; CD4; CD8; T cells; surface expression; peripheral blood