Dual Functions of Highly Potent Graphene Derivative鈥揚oly-l-Lysine Composites To Inhibit Bacteria and Support Human Cells
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- 作者：Surajit Some ; Seok-Man Ho ; Pooja Dua ; Eunhee Hwang ; Young Hun Shin ; HeeJoun Yoo ; Jong-Sun Kang ; Dong-ki Lee ; Hyoyoung Lee
- 刊名：ACS Nano
- 出版年：2012
- 出版时间：August 28, 2012
- 年：2012
- 卷：6
- 期：8
- 页码：7151-7161
- 全文大小：824K
- 年卷期：v.6,no.8(August 28, 2012)
- ISSN：1936-086X
文摘
Dual-function poly(l-lysine) (PLL) composites that function as antibacterial agents and promote the growth of human cell culture have been sought by researchers for a long period. In this paper, we report the preparation of new graphene derivative鈥揚LL composites via electrostatic interactions and covalent bonding between graphene derivatives and PLL. The resulting composites were characterized by infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. The novel dual function of PLL composites, specifically antibacterial activity and biocompatibility with human cells [human adipose-derived stem cells and non-small-cell lung carcinoma cells (A549)], was carefully investigated. Graphene鈥揇S鈥揚LL composites composed of 4-carboxylic acid benzene diazonium salt (DS) generated more anionic carboxylic acid groups to bind to cationic PLLs, forming the most potent antibacterial agent among PLL and PLL composites with high biocompatibility with human cell culture. This dual functionality can be used to inhibit bacterial growth while enhancing human cell growth.