Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

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• 作者：Tianfeng Chen ; Yanan Liu ; Wen-Jie Zheng ; Jie Liu ; Yum-Shing Wong
• 刊名：Inorganic Chemistry
• 出版年：2010
• 出版时间：July 19, 2010
• 年：2010
• 卷：49
• 期：14
• 页码：6366-6368
• 全文大小：729K
• 年卷期：v.49,no.14(July 19, 2010)
• ISSN：1520-510X

文摘

The limitations of cisplatin-based chemotherapy, including high toxicity, undesirable side effects, and drug resistance, have motivated extensive investigations into alternative metal-based cancer therapies. Ruthenium (Ru) possesses several favorable properties suited to rational anticancer drug design and biological applications. In the present study, we synthesized a series of ruthenium polypyridyl complexes containing N,N-chelating ligands, examined their anticancer activities, and elucidated the molecular mechanisms through which they caused the cancer cell death. The results demonstrated that [Ru(phen)₂-p-MOPIP](PF₆)₂·2H₂O (RuPOP), a complex with potent antiproliferative activity, is able to induce mitochondria-mediated and caspase-dependent apoptosis in human cancer cells. On the basis of these results, we suggest that RuPOP may be a candidate for further evaluation as a chemopreventive and chemotherapeutic agent for human cancers, especially for melanoma.