Biotransformation of Turmerones by Aspergillus niger

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• 作者：Mai Fujiwara ; Shinsuke Marumoto ; Nobuo Yagi ; Mitsuo Miyazawa
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：January 28, 2011
• 年：2011
• 卷：74
• 期：1
• 页码：86-89
• 全文大小：116K
• 年卷期：v.74,no.1(January 28, 2011)
• ISSN：1520-6025

文摘

Biotransformation studies conducted on (+)-(S)-ar-turmerone (1) and (+)-(S)-dihydro-ar-turmerone (2) by the fungus Aspergillus niger have revealed that 1 was metabolized to give four oxidized metabolites, (+)-(7S)-hydroxydehydro-ar-todomatuic acid (3), (+)-(7S,10E)-12-hydroxydehydro-ar-todomatuic acid (4), (+)-(7S,10E)-7,12-dihydroxydehydro-ar-todomatuic acid (5), and (+)-(7S)-15-carboxy-9,13-epoxy-7-hydroxy-9,13-dehydro-ar-curcumene (6), and (+)-(S)-dihydro-ar-turmerone (2) was metabolized to (+)-7,11-dihydroxy-ar-todomatuic acid (7). Metabolites 3鈭?b>7 were characterized using spectroscopic techniques. Metabolites 3鈭?b>7 inhibited acetylcholinesterase (AChE) although less so than the parent substrates.