A Practical Synthesis of Regioisomeric 6- and 7-Methoxytetrahydro-3-benzazepines

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• 作者：Jimmy T. Liang ; Jing Liu ; Brock T. Shireman ; Vi Tran ; Xiaohu Deng ; Neelakandha S. Mani
• 刊名：Organic Process Research & Development
• 出版年：2010
• 出版时间：March 19, 2010
• 年：2010
• 卷：14
• 期：2
• 页码：380-385
• 全文大小：264K
• 年卷期：v.14,no.2(March 19, 2010)
• ISSN：1520-586X

文摘

A concise and versatile synthetic route for 6- and 7-methoxy tetrahydro-3-benzazepines is described. The key feature of the synthesis is a one-pot acylation/cyclization/elimination sequence to construct either of the isomeric dihydrobenzazepine ring systems from the same starting material. The route is high yielding and chromatography-free.