Cytotoxic and HIF-1α Inhibitory Compounds from Crossosoma bigelovii
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- 作者：Paul Klausmeyer ; Qin Zhou ; Dominic A. Scudiero ; Badarch Uranchimeg ; Giovanni Melillo ; John H. Cardellina ; ; Robert H. Shoemaker ; Ching-jer Chang ; Thomas G. McCloud
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：May 22, 2009
- 年：2009
- 卷：72
- 期：5
- 页码：805-812
- 全文大小：293K
- 年卷期：v.72,no.5(May 22, 2009)
- ISSN：1520-6025
文摘
Cytotoxicity-guided fractionation of an organic solvent extract of the plant Crossosoma bigelovii led to the discovery of a new strophanthidin glycoside (1) and two new 2-methylchromone glycosides (2 and 3). Also isolated were the known chromones eugenin and noreugenin, the indole alkaloid ajmalicine, the dibenzylbutane lignan secoisolariciresinol, the dibenzylbutyrolactone lignan matairesinol, and the furanone 5-tetradec-5-enyldihydrofuran-2-one. Further investigation into the biological properties of strophanthidin glycosides revealed a connection between inhibition of HIF-1 activation and the glycosylation of the genin. This work is the first published study of the bioactive phytochemicals of the family Crossosomataceae.