Stereoselective Syntheses of the C(1)−C(9) Fragment of Amphidinolide C

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• 作者：Robert H. Bates ; J. Brad Shotwell ; William R. Roush
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：October 2, 2008
• 年：2008
• 卷：10
• 期：19
• 页码：4343-4346
• 全文大小：181K
• 年卷期：v.10,no.19(October 2, 2008)
• ISSN：1523-7052

文摘

Stereoselective syntheses of the C(1)−C(9) fragments 18 and 28 of amphidinolide C have been developed. The first-generation sequence involves a diastereoselective chelate-controlled [3 + 2]-annulation reaction of 6 and 7, while the second-generation synthesis involves an intramolecular hetero-Michael cyclization of 8.