Incarvilleatone, a New Cyclohexylethanoid Dimer from Incarvillea younghusbandii and Its Inhibition against Nitric Oxide (NO) Release
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- 作者：Yan-Ping Gao ; Yun-Heng Shen ; Shou-De Zhang ; Jun-Mian Tian ; Hua-Wu Zeng ; Ji Ye ; Hui-Liang Li ; Lei Shan ; Wei-Dong Zhang
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：April 20, 2012
- 年：2012
- 卷：14
- 期：8
- 页码：1954-1957
- 全文大小：226K
- 年卷期：v.14,no.8(April 20, 2012)
- ISSN：1523-7052
文摘
Incarvilleatone (1), an unprecedented dimeric cyclohexylethanoid analog with a racemic nature, was isolated from the whole plant of Incarvillea younghusbandii. HPLC chiral separation of 1 gave two enantiomers (鈭?-incarvilleatone and (+)-incarvilleatone. The structure of 1 was established by spectroscopic methods and single crystal X-ray diffraction. The absolute configurations of enantiomers were determined by quantum mechanical calculation. (鈭?-Incarvilleatone exhibited a potent inhibitory effect against NO production in LPS-induced RAW264.7 macrophages.