Iron-Catalyzed Radical Oxidative Coupling Reaction of Aryl Olefins with 1,3-Dithiane

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• 作者：Wenbin Du ; Lixia Tian ; Junshan Lai ; Xing Huo ; Xingang Xie ; Xuegong She ; Shouchu Tang
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：May 2, 2014
• 年：2014
• 卷：16
• 期：9
• 页码：2470-2473
• 全文大小：278K
• 年卷期：v.16,no.9(May 2, 2014)
• ISSN：1523-7052

文摘

An alternative method to an iron-catalyzed radical oxidative cross-coupling reaction followed by 2-chloro-1,3-dithiane and aryl olefins for the synthesis of 尾-chloro substituent 1,3-dithiane products is presented. The described method has the advantage of mildness of the reaction conditions and tolerates a variety of functional groups. Preliminary mechanistic studies have confirmed the first example of a coupling of 1,3-dithiane with unactivated alkenes that proceeds via an iron-catalyzed oxidative radical intermediate along the reaction pathway.