Asymmetric Total Synthesis and Structural Elucidation of NFAT-68

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• 作者：Lin Wang ; Yumeng Xi ; Shouliang Yang ; Rong Zhu ; Yufan Liang ; Jiahua Chen ; Zhen Yang
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：January 7, 2011
• 年：2011
• 卷：13
• 期：1
• 页码：74-77
• 全文大小：315K
• 年卷期：v.13,no.1(January 7, 2011)
• ISSN：1523-7052

文摘

Total synthesis of NFAT-68 (7) has been achieved and its relative stereochemistry has been determined. A key step thereof is the utilization of the chelation-controlled vinylogous Mukaiyama aldol reaction (VMAR) to stereoselectively synthesize the syn-aldol product 8. This developed chemistry is anticipated to have wider application in total syntheses of many other natural products.