3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms
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- 作者：Edmund L. Ellsworth ; Tuan P. Tran ; H. D. Hollis Showalter ; Joseph P. Sanchez ; Brian M. Watson ; Michael A. Stier ; John M. Domagala ; Stephen J. Gracheck ; E. Themis Joannides ; Martin A. Shapiro ; Steve A.
- 刊名：Journal of Medicinal Chemistry
- 出版年：2006
- 出版时间：November 2, 2006
- 年：2006
- 卷：49
- 期：22
- 页码：6435 - 6438
- 全文大小：48K
- 年卷期：v.49,no.22(November 2, 2006)
- ISSN：1520-4804
文摘
The 3-aminoquinzolinediones represent a new series ofantibacterial agents structurally related to the fluoroquinolones. Theyare inhibitors of bacterial gyrase and topoisomerase IV and demonstrateclinically useful antibacterial activity against fastidious Gram-negativeand Gram-positive organisms, including multidrug- and fluoroquinolone-resistant organisms. These agents also demonstrate in vivo efficacyin murine systemic infection models.