Mollolide A, a Diterpenoid with a New 1,10:2,3-Disecograyanane Skeleton from the Roots of Rhododendron molle

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• 作者：Yong Li ; Yun-Bao Liu ; Jian-Jun Zhang ; Yu-Huan Li ; Jian-Dong Jiang ; Shi-Shan Yu ; Shuang-Gang Ma ; Jing Qu ; Hai-Ning Lv
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 21, 2013
• 年：2013
• 卷：15
• 期：12
• 页码：3074-3077
• 全文大小：260K
• 年卷期：v.15,no.12(June 21, 2013)
• ISSN：1523-7052

文摘

Mollolide A (1), a diterpenoid featuring a new 1,10:2,3-disecograyanane skeleton, was isolated from the roots of Rhododendron molle. Its structure was elucidated through extensive MS, IR, and NMR spectroscopy analyses. The absolute configuration was determined by single-crystal X-ray diffraction of its p-bromobenzoate derivative (1b). Compound 1 exhibits a significant analgesic effect at a dose of 20 mg/kg and antiviral activity against the Coxsackie B3 virus with an IC₅₀ value of 27.7 渭M.