Antiviral Spirooliganones A and B with Unprecedented Skeletons from the Roots of Illicium oligandrum

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• 作者：Shuang-Gang Ma ; Rong-Mei Gao ; Yu-Huan Li ; Jian-Dong Jiang ; Ning-Bo Gong ; Li Li ; Yang L眉 ; Wen-Zhao Tang ; Yun-Bao Liu ; Jing Qu ; Hai-Ning L眉 ; Yong Li ; Shi-Shan Yu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：September 6, 2013
• 年：2013
• 卷：15
• 期：17
• 页码：4450-4453
• 全文大小：259K
• 年卷期：v.15,no.17(September 6, 2013)
• ISSN：1523-7052

文摘

Two novel spirooliganones A (1) and (2), a pair of spiro carbon epimers, with a rare dioxaspiro skeleton were isolated from the roots of Illicium oligandrum. The structures were fully determined by spectroscopic analysis and chemical methods, especially modified Mosher鈥檚 method, and X-ray diffraction analysis. Spirooliganone B was found to exhibit more potent activities against coxsackie virus B3 and influenza virus A (H3N2) (IC₅₀ 3.70鈥?.05 渭M) than spirooliganone A. The biosynthetic pathway involving a hetero-Diels鈥揂lder reaction of the epimers was proposed.