Residue Depletion of Tilmicosin in Cattle after Subcutaneous Administration

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• 作者：Haiyang Jiang ; Shuangyang Ding ; Jiancheng Li ; Dianjin An ; Cun Li ; and Jianzhong Shen
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2006
• 出版时间：July 12, 2006
• 年：2006
• 卷：54
• 期：14
• 页码：5208 - 5213
• 全文大小：113K
• 年卷期：v.54,no.14(July 12, 2006)
• ISSN：1520-5118

文摘

A study of tissue residue depletion of tilmicosin in cattle was conducted after a single subcutaneousinjection at the therapeutic level of 10 mg per kg body weight. Eighteen cross cattle were treatedwith the tilmicosin oil formulation (30%). Three treated animals (two males and one female) wereselected randomly to be scarified at 1, 7, 14, 28, and 35 days withdrawal after injection. Samples ofthe injection site and of muscle, liver, kidney, and fat were collected. Tilmicosin residue concentrationswere determined using a high-performance liquid chromatography (HPLC) method with a UV detectorat 290 nm. Using a statistical method recommended by the Committee for Veterinary Medical Productsof European Medical Evaluation Agency, the withdrawal time of 34 days was established when alltissue residues except samples in the injection site were below the accepted maximum residue limits.Keywords: Tilmicosin; residue; depletion; cattle; withdrawal time