Guanacastane Diterpenoids from the Plant Endophytic Fungus Cercospora sp.

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• 作者：Yu Feng ; Fengxia Ren ; Shubin Niu ; Lin Wang ; Li Li ; Xingzhong Liu ; Yongsheng Che
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：873-881
• 全文大小：408K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

Cercosporenes A鈥揊 (1鈥?, respectively), six new guanacastane diterpenes, including a homodimer (5) and a heterodimer (6), were isolated from the crude extract of the fungus Cercospora sp., endophytic to the medicinal plant Fallopia japonica. The structures of 1鈥? were elucidated by nuclear magnetic resonance experiments, and 4 and 5 were further confirmed by X-ray crystallography. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations, whereas that of 6 was deduced by the application of the circular dichroism exciton chirality method. In addition to its cytotoxicity against a panel of five human tumor cell lines, HeLa, A549, MCF-7, HCT116, and T24, heterodimer 6 also induced autophagy in HCT116 cells.