Isolation and Synthesis of Antiproliferative Eupolauridine Alkaloids of Ambavia gerrardii from the Madagascar Dry Forest

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• 作者：Ende Pan ; Shugeng Cao ; Peggy J. Brodie ; Martin W. Callmander ; Richard Randrianaivo ; Stephan Rakotonandrasana ; Etienne Rakotobe ; Vincent E. Rasamison ; Karen TenDyke ; Yongchun Shen ; Edward M. Suh ; David G. I. Kingston
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1169-1174
• 全文大小：818K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Investigation of the Madagascan endemic plant Ambavia gerrardii for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the three new alkaloids 8-hydroxyeupolauridine (1), 9-methoxyeupolauridine 1-oxide (2), and 11-methoxysampangine (3) and the three known alkaloids 4鈥?b>6. The structures of 1 and 2 were confirmed by synthesis. Compounds 3, 4, and 6 showed moderate to good antiproliferative activities, with IC₅₀ values of 10.3, 3.5, and 0.60 渭M, respectively, against the A2780 human ovarian cancer cell line and with IC₅₀ values of 0.57, 1.77, and 0.58 渭M, respectively, against the H460 human lung cancer cell line.