Palladium-Catalyzed Intermolecular Aminofluorination of Styrenes

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• 作者：Shuifa Qiu ; Tao Xu ; Juan Zhou ; Yinlong Guo ; Guosheng Liu
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：March 10, 2010
• 年：2010
• 卷：132
• 期：9
• 页码：2856-2857
• 全文大小：176K
• 年卷期：v.132,no.9(March 10, 2010)
• ISSN：1520-5126

文摘

A novel palladium-catalyzed intermolecular aminofluorination of styrenes, with N-fluorobenzenesulfonimide (NFSI) functioning not only as a fluorinating reagent but also as an aminating reagent, has been developed. The reaction afforded vicinal fluoroamine products with very high regioselectivity. This transformation may involve fluoropalladation of styrene as a key step for C−F bond formation. The bidental nitrogen ligand is crucial to achieving the transformation successfully.