Cationic Gold(I)-Catalyzed Intramolecular Cyclization of γ-Hydroxyalkynones into 3(2H)-Furanones

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• 作者：Masahiro Egi ; Kenji Azechi ; Moriaki Saneto ; Kaori Shimizu ; Shuji Akai
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：March 19, 2010
• 年：2010
• 卷：75
• 期：6
• 页码：2123-2126
• 全文大小：743K
• 年卷期：v.75,no.6(March 19, 2010)
• ISSN：1520-6904

文摘

The combination of (p-CF₃C₆H₄)₃PAuCl and AgOTf generates a powerful catalyst for the intramolecular cyclizations of readily available γ-hydroxyalkynones under mild conditions. The substituted 3(2H)-furanones are obtained in 55−94% yields. This method is also applicable to the preparation of 2,3-dihydro-4H-pyran-4-ones.