A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2鈥?quinoline] Scaffold

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• 作者：Feng Shi ; Gui-Juan Xing ; Ren-Yi Zhu ; Wei Tan ; Shujiang Tu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 4, 2013
• 年：2013
• 卷：15
• 期：1
• 页码：128-131
• 全文大小：288K
• 年卷期：v.15,no.1(January 4, 2013)
• ISSN：1523-7052

文摘

The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2鈥?quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 dr's, up to 97% ee).