Nickel-Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides

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• 作者：Xuan Wang ; Shulin Wang ; Weichao Xue ; Hegui Gong
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：September 16, 2015
• 年：2015
• 卷：137
• 期：36
• 页码：11562-11565
• 全文大小：397K
• ISSN：1520-5126

文摘

A mild Ni-catalyzed reductive arylation of tertiary alkyl halides with aryl bromides has been developed that delivers products bearing all-carbon quaternary centers in moderate to excellent yields with excellent functional group tolerance. Electron-deficient arenes are generally more effective in inhibiting alkyl isomerization. The reactions proceed successfully with pyridine or 4-(dimethylamino)pyridine, while imidazolium salts slightly enhance the coupling efficiency.