Preparation of 4-Allylisoindoline via a Kumada Coupling with Allylmagnesium Chloride

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• 作者：Michael J. Zacuto ; C. Scott Shultz ; Michel Journet
• 刊名：Organic Process Research & Development
• 出版年：2011
• 出版时间：January 21, 2011
• 年：2011
• 卷：15
• 期：1
• 页码：158-161
• 全文大小：150K
• 年卷期：v.15,no.1(January 21, 2011)
• ISSN：1520-586X

文摘

A practical, cost-effective Kumada coupling for the preparation of 4-allylisoindoline has been developed. The first catalyst screen for this reaction with allylmagnesium reagents is described. The challenges associated with product isomerization have been minimized by a thorough understanding of the reaction parameters. Additionally, a novel workup protocol has been developed to render Mg salts soluble in aqueous media at pH 10.