Synthesis of Azaheterocycles from Aryl Ketone O-Acetyl Oximes and Internal Alkynes by Cu鈥揜h Bimetallic Relay Catalysts

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• 作者：Pei Chui Too ; Sze Hui Chua ; Siong Heng Wong ; Shunsuke Chiba
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：August 5, 2011
• 年：2011
• 卷：76
• 期：15
• 页码：6159-6168
• 全文大小：1045K
• 年卷期：v.76,no.15(August 5, 2011)
• ISSN：1520-6904

文摘

A synthetic method for azaheterocycles from aryl ketone O-acetyl oximes and internal alkynes has been developed by using the Cu(OAc)₂鈥揫Cp*RhCl₂]₂ bimetallic catalytic system. The reactions proceeded with both of anti- and syn-isomers of oximes with a wide scope of substituents. The Cu鈥揜h bimetallic system could be applied for the synthesis of isoquinolines as well as 尾-carboline, furo[2.3-c]pyridine, pyrrolo[2,3-c]pyridine, and thieno[2,3-c]pyridine derivatives.