文摘
Along with four known terpenoids (1鈥?b>4), eight new dinorditerpenes (5鈥?b>12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4鈥?b>6 were determined by the Mosher鈥檚 method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC50 values of 5.6, 5.0, 7.5, and 6.6 渭M, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.