Isoflavones Suppress the Expression of the Fc蔚RI High-Affinity Immunoglobulin E Receptor Independent of the Estrogen Receptor
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- 作者：Shuya Yamashita ; Shuntaro Tsukamoto ; Motofumi Kumazoe ; Yoon-hee Kim ; Koji Yamada ; Hirofumi Tachibana
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：August 29, 2012
- 年：2012
- 卷：60
- 期：34
- 页码：8379-8385
- 全文大小：502K
- 年卷期：v.60,no.34(August 29, 2012)
- ISSN：1520-5118
文摘
Isoflavones found in soybeans and soy products possess clinically relevant properties. However, the anti-allergic effect of isoflavones has been poorly studied. We examined the effects of isoflavones, genistein, daidzein, and equol, on the expression of the high-affinity immunoglobulin E (IgE) receptor, Fc蔚RI, which plays a central role in IgE-mediated allergic response. Flow cytometric analysis showed that all of these isoflavones reduced the cell surface expression of Fc蔚RI on mouse bone-marrow-derived mast cells and human basophilic KU812 cells. All isoflavones decreased the levels of the Fc蔚RI伪 mRNA in the cells. Genistein reduced the mRNA expression of the 尾 chain, and daidzein and equol downregulated that of the 纬 chain. The suppressive effects of isoflavones on Fc蔚RI expression were unaffected by ICI 182,780, an estrogen receptor antagonist, suggesting that these effects were independent of estrogen receptors.