Total Synthesis of (±)-Phenserine via [4+1] Cyclization of a Bis(alkylthio)carbene and an Indole Isocyanate

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• 作者：James H. Rigby ; Shyama Sidique
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：March 29, 2007
• 年：2007
• 卷：9
• 期：7
• 页码：1219 - 1221
• 全文大小：64K
• 年卷期：v.9,no.7(March 29, 2007)
• ISSN：1523-7052

文摘

A total synthesis of acetylcholine blocking agent, phenserine, has been achieved by employing a [4+1] cyclization between an appropriatelysubstituted indole isocyanate and a bis(alkylthio)carbene.