Modular Approach to 9-Monosubstituted Fluorene Derivatives Using MoV Reagents

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• 作者：Peter Franzmann ; Simon Trosien ; Moritz Schubert ; Siegfried R. Waldvogel
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：18
• 期：5
• 页码：1182-1185
• 全文大小：356K
• ISSN：1523-7052

文摘

Oxidative coupling using molybdenum(V) reagents provides fast access to highly functionalized 9-monosubstituted fluorenes. This synthetic approach is highly modular, is high yielding, and tolerates a variety of labile moieties, e.g. amides or iodo groups. The established protocol leads to promising precursors for pharmacologically important analogues of melatonin.