Design of PLGA Based Nanoparticles for Imaging Guided Applications
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- 作者：Rodolfo Nicol谩s Mariano ; Diego Alberti ; Juan Carlos Cutrin ; Simonetta Geninatti Crich ; Silvio Aime
- 刊名：Molecular Pharmaceutics
- 出版年：2014
- 出版时间：November 3, 2014
- 年：2014
- 卷：11
- 期：11
- 页码：4100-4106
- 全文大小：304K
- ISSN：1543-8392
文摘
An amphiphilic Gd(III) complex has been efficiently loaded in polylactic-co-glycolic acid nanoparticles (PLGA-NPs) to yield a novel, high sensitive magnetic resonance imaging (MRI) contrast agent for imaging guided drug delivery applications. As the Gd(III) complex is soluble in organic solvents, the nanoparticles were prepared as oil/water emulsions. PLGA-NPs were stable, in buffer, for more than 1 week without any release of the incorporated agents. The millimolar relaxivity of the Gd(III) complex incorporated in the particles (140 nm diameter) was of 21.7 mM鈥? s鈥? at 21.5 MHz, a value that is about 5 times higher than that observed with the commercially available contrast agents used in clinic. The relaxometric efficiency of these particles resulted inversely proportional to the particle size measured by dynamic light scattering. The high stability and sensitivity of PLGA-NPs allowed their accumulation in vivo in murine melanoma xenograft as shown in the corresponding MR images. Once loaded with drug and contrast agents, PLGA nanoparticles can be proposed as efficient theranostic MRI agents.