High Efficiency of Functional Carbon Nanodots as Entry Inhibitors of Herpes Simplex Virus Type 1

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• 作者：Alexandre Barras ; Quentin Pagneux ; Famara Sane ; Qi Wang ; Rabah Boukherroub ; Didier Hober ; Sabine Szunerits
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：April 13, 2016
• 年：2016
• 卷：8
• 期：14
• 页码：9004-9013
• 全文大小：657K
• 年卷期：0
• ISSN：1944-8252

文摘

Nanostructures have been lately identified as an efficient therapeutic strategy to modulate viral attachment and entry. The high concentrations of ligands present on nanostructures can considerably enhance affinities toward biological receptors. We demonstrate here the potential of carbon nanodots (C-dots) surface-functionalized with boronic acid or amine functions to interfere with the entry of herpes simplex virus type 1 (HSV-1). C-dots formed from 4-aminophenylboronic acid hydrochloride (4-AB/C-dots) using a modified hydrothermal carbonization are shown to prevent HSV-1 infection in the nanograms per milliliter concentration range (EC₅₀ = 80 and 145 ng mL^–1 on Vero and A549 cells, respectively), whereas the corresponding C-dots formed from phenylboronic acid (B/C-dots) have no effects even at high concentrations. Some of the presented results also suggest that C-dots are specifically acting on the early stage of virus entry through an interaction with the virus and probably the cells at the same time.