Continuous Recycling of Homogeneous Pd/Cu Catalysts for Cross-Coupling Reactions

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• 作者：Siddharth Sharma ; K. C. Basavaraju ; Ajay K. Singh ; Dong-Pyo Kim
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 1, 2014
• 年：2014
• 卷：16
• 期：15
• 页码：3974-3977
• 全文大小：251K
• ISSN：1523-7052

文摘

Given the importance of homogeneous catalysts recycling in organic chemistry, we have developed a unique microfluidic loop system for automated continuous recirculation of a soluble polymer supported metal catalyst for novel isocyanide cross-coupling reactions under thermomorphic multicomponent solvent (TMS) conditions. Our system provides an innovative approach for the chemical library synthesis of quinazolinone derivatives as well as an important intermediate of Merck鈥檚 LTD4 antagonist 鈥淪ingulair鈥?with efficient continuous homogeneous catalyst recycling.