A Convergent Synthesis of AR-C123196 Utilising Reaction Between a Cyclic Carbonate and a Phenol for Aryl Alkyl Ether Formation

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• 作者：Glyn L. Allsop ; Andrea J. Cole ; Melvyn E. Giles ; Eric Merifield ; Allison J. Noble ; Michael A. Pritchett ; Lindsay A. Purdie ; John T. Singleton
• 刊名：Organic Process Research & Development
• 出版年：2009
• 出版时间：July 17, 2009
• 年：2009
• 卷：13
• 期：4
• 页码：751-759
• 全文大小：184K
• 年卷期：v.13,no.4(July 17, 2009)
• ISSN：1520-586X

文摘

The development of a convergent synthesis of AR-C123196 is reported in which the alkyl aryl ether linkage was formed by nucleophilic attack of a phenolic hydroxyl group onto a cyclic carbonate. This approach was successfully operated on a multikilogram scale.