Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C60(OH)x and Gd@C60[C(COOH2)]10
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- 作者：Sabrina Laus ; Balaji Sitharaman ; É ; va Tó ; th ; Robert D. Bolskar ; Lothar Helm ; Subashini Asokan ; Michael S. Wong ; Lon J. Wilson ; and André ; E. Merbach
- 刊名：Journal of the American Chemical Society
- 出版年：2005
- 出版时间：July 6, 2005
- 年：2005
- 卷：127
- 期：26
- 页码：9368 - 9369
- 全文大小：37K
- 年卷期：v.127,no.26(July 6, 2005)
- ISSN：1520-5126
文摘
A combined proton relaxivity and dynamic light scattering study has shown that aggregates formed in aqueous solution of water-soluble gadofullerenes can be disrupted by addition of salts. The salt content of fullerene-based materials will strongly influence properties related to aggregation phenomena, therefore, their behavior in biological or medical applications. In particular, the relaxivity of gadofullerenes decreases dramatically with phosphate addition. Moreover, real biological fluids present a rather high salt concentration which will have consequences on fullerene aggregation and influence fullerene-based drug delivery.