Diastereoselective Synthesis of -Methyl and -Hydroxy- 详细信息    查看全文

• 作者：Brad E. Sleebs ; Andrew B. Hughes
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：April 27, 2007
• 年：2007
• 卷：72
• 期：9
• 页码：3340 - 3352
• 全文大小：231K
• 年卷期：v.72,no.9(April 27, 2007)
• ISSN：1520-6904

文摘

1,3-Oxazinan-6-ones have been utilized in a series of enolate reactions to produce 5-hydroxy and 5-alkyl-4-substituted-1,3-oxazinan-6-ones with excellent trans diastereoselectivity. Highlighting the versatilityof the oxazinanone, a number of transformations were performed to produce a variety of protected N-Hand N-methyl -hydroxy- and -methyl--amino acids.