Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)
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- 作者：Jun Li ; Stephanie Y. Chen ; James J. Li ; Haixia Wang ; Andres S. Hernandez ; Shiwei Tao ; Christa M. Musial ; Fucheng Qu ; Stephen Swartz ; Sam T. Chao ; Neil Flynn ; Brian J. Murphy ; Dorothy A. Slusarchyk ; Ra
- 刊名：Journal of Medicinal Chemistry
- 出版年：2007
- 出版时间：November 29, 2007
- 年：2007
- 卷：50
- 期：24
- 页码：5890 - 5893
- 全文大小：74K
- 年卷期：v.50,no.24(November 29, 2007)
- ISSN：1520-4804
文摘
A tetrazole-based peptidomimetic 2 (BMS-317180) wasdiscovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellentsafety profile in preclinical studies. The compound was advanced intoclinical development.