Octulosonic Acid Derivatives from Roman Chamomile (Chamaemelum nobile) with Activities against Inflammation and Metabolic Disorder

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• 作者：Jianping Zhao ; Shabana I. Khan ; Mei Wang ; Yelkaira Vasquez ; Min Hye Yang ; Bharathi Avula ; Yan-Hong Wang ; Cristina Avonto ; Troy J. Smillie ; Ikhlas A. Khan
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：March 28, 2014
• 年：2014
• 卷：77
• 期：3
• 页码：509-515
• 全文大小：264K
• 年卷期：v.77,no.3(March 28, 2014)
• ISSN：1520-6025

文摘

Six new octulosonic acid derivatives (1鈥?b>6) were isolated from the flower heads of Roman chamomile (Chamaemelum nobile). Their structures were elucidated by means of spectroscopic interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation and metabolic disorder such as NAG-1, NF-魏B, iNOS, ROS, PPAR伪, PPAR纬, and LXR. Similar to the action of NSAIDs, all the six compounds (1鈥?b>6) increased NAG-1 activity 2鈥?-fold. They also decreased cellular oxidative stress by inhibiting ROS generation. Compounds 3, 5, and 6 activated PPAR纬 1.6鈥?.1-fold, while PPAR伪 was activated 1.4-fold by compounds 5 and 6 only. None of the compounds showed significant activity against iNOS or NF-魏B. This is the first report of biological activity of octulosonic acid derivatives toward multiple pathways related to inflammation and metabolic disorder. The reported anti-inflammatory, hypoglycemic, antiedemic, and antioxidant activities of Roman chamomile could be partly explained as due to the presence of these constituents.