Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 2. Antiproliferative and Antitubulin Activities of Pyrano[3,2-c]pyridones and Pyrano[3,2-c]quinolon
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- 作者：Igor V. Magedov ; Madhuri Manpadi ; Marcia A. Ogasawara ; Adriana S. Dhawan ; Snezna Rogelj ; Severine Van slambrouck ; Wim F. A. Steelant ; Nikolai M. Evdokimov ; Pavel Y. Uglinskii ; Eerik M. Elias ; Erica J.
- 刊名：Journal of Medicinal Chemistry
- 出版年：2008
- 出版时间：April 24, 2008
- 年：2008
- 卷：51
- 期：8
- 页码：2561 - 2570
- 全文大小：771K
- 年卷期：v.51,no.8(April 24, 2008)
- ISSN：1520-4804
文摘
Pyrano[3,2-c]pyridone and pyrano[3,2-c]quinolone structural motifs are commonly found in alkaloids manifesting diverse biological activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes, we developed compound libraries based on these privileged heterocyclic scaffolds. The selected library members display low nanomolar antiproliferative activity and induce apoptosis in human cancer cell lines. Mechanistic studies reveal that these compounds induce cell cycle arrest in the G2/M phase and block in vitro tubulin polymerization. Because of the successful clinical use of microtubule-targeting agents, these heterocyclic libraries are expected to provide promising new leads in anticancer drug design.