Meroterpenoids from the Alga-Derived Fungi Penicillium thomii Maire and Penicillium lividum Westling
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- 作者：Olesya I. Zhuravleva ; Maria P. Sobolevskaya ; Elena V. Leshchenko ; Natalya N. Kirichuk ; Vladimir A. Denisenko ; Pavel S. Dmitrenok ; Sergey A. Dyshlovoy ; Alexander M. Zakharenko ; Natalya Yu. Kim ; Shamil Sh. Afiyatullov
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：June 27, 2014
- 年：2014
- 卷：77
- 期：6
- 页码：1390-1395
- 全文大小：243K
- ISSN：1520-6025
文摘
Ten new austalide meroterpenoids (1鈥?b>10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher鈥檚 method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1鈥?b>5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-尾-pan class="smallcaps">d pan>-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.